functional polymorphisms in prodh are associated with risk and protection for schizophrenia and fronto-striatal structure and function在prodh功能多态性与风险和保护精神分裂症和fronto-striatal结构和功能.pdfVIP

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functional polymorphisms in prodh are associated with risk and protection for schizophrenia and fronto-striatal structure and function在prodh功能多态性与风险和保护精神分裂症和fronto-striatal结构和功能.pdf

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functional polymorphisms in prodh are associated with risk and protection for schizophrenia and fronto-striatal structure and function在prodh功能多态性与风险和保护精神分裂症和fronto-striatal结构和功能

Functional Polymorphisms in PRODH Are Associated with Risk and Protection for Schizophrenia and Fronto- Striatal Structure and Function 1,2 2¤a 2 2 Lucas Kempf , Kristin K. Nicodemus , Bhaskar Kolachana , Radhakrishna Vakkalanka , Beth A. 2,3 2¤b 2 2,3 2 Verchinski , Michael F. Egan , Richard E. Straub , Venkata A. Mattay , Joseph H. Callicott , Daniel R. Weinberger2*, Andreas Meyer-Lindenberg1,2,3,4* 1 Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Neuroimaging Core Facility, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Central Institute of Mental Health, Mannheim, Germany Abstract PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that functional polymorphisms in PRODH are associated with schizophrenia, with protective and risk alleles having opposite effects on POX activity. Using a multimodal imaging genetics approach, we demonstrate that haplotypes constructed from these ri