functionalization of titanium with chitosan via silanation evaluation of biological and mechanical performances功能化的钛通过silanation评价与壳聚糖的生物和机械性能.pdfVIP

Functionalization of Titanium with Chitosan via Silanation: Evaluation of Biological and Mechanical Performances 1 ´ ` 1 ´ 2 1 1,3 Pauline Renoud , Berangere Toury , Stephane Benayoun , Ghania Attik , Brigitte Grosgogeat * ´ ´ ´ ` 1 Laboratoire des Multimateriaux et Interfaces, Universite Lyon 1, Universite de Lyon, Villeurbanne, France, 2 Laboratoire de Tribologie et Dynamique des Systemes, Ecole Centrale de Lyon, Ecully, France, 3 Service de Traitements et de Consultations Dentaires, Hospices Civils de Lyon, Lyon, France Abstract Complications in dentistry and orthopaedic surgery are mainly induced by peri-implant bacterial infections and current implant devices do not prevent such infections. The coating of antibacterial molecules such as chitosan on its surface would give the implant bioactive properties. The major challenge of this type of coating is the attachment of chitosan to a metal substrate. In this study, we propose to investigate the functionalization of titanium with chitosan via a silanation. Firstly, the surface chemistry and mechanical properties of such coating were evaluated. We also verified if the coated chitosan retained its biocompatibility with the peri-implant cells, as well as its antibacterial properties. FTIR and Tof-SIMS analyses confirmed the presence of chitosan on the titanium surface. This coating showed great scratch resistance and was strongly adhesive to the substrate. These mechanical properties were consistent with an implantology application. The Chitosan- coated surfaces showed