functionally suppressive cd8 t regulatory cells are increased in patients with multiple myeloma a cause for immune impairment功能抑制的cd8 t调节细胞增加多发性骨髓瘤患者的免疫损伤的原因.pdfVIP

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2017-09-01 发布于上海
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functionally suppressive cd8 t regulatory cells are increased in patients with multiple myeloma a cause for immune impairment功能抑制的cd8 t调节细胞增加多发性骨髓瘤患者的免疫损伤的原因.pdf

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functionally suppressive cd8 t regulatory cells are increased in patients with multiple myeloma a cause for immune impairment功能抑制的cd8 t调节细胞增加多发性骨髓瘤患者的免疫损伤的原因

Functionally Suppressive CD8 T Regulatory Cells Are Increased in Patients with Multiple Myeloma: A Cause for Immune Impairment 1,2 1 1,3 1 2,3 Karthick Raja Muthu Raja *, Lenka Kubiczkova , Lucie Rihova , Martin Piskacek , Pavla Vsianska , 5 4 1,2,3,4 Renata Hezova , Ludek Pour , Roman Hajek 1 Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2 Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic, 3 Department of Clinical Hematology, University Hospital, Brno, Czech Republic, 4 Department of Internal Medicine, Hemato-oncology, University Hospital, Brno, Czech Republic, 5 Central European Institute of Technology, Masaryk University, Brno, Czech Republic Abstract Background: Multiple myeloma (MM) is a plasma cell malignancy frequently associated with impaired immune cell numbers and functions. In MM, several studies have previously shown that CD4 regulatory T (Treg) cells hamper effector T cell functions and enhance immune dysfunction. In this study, we aimed to prove the presence of functionally suppressive Treg cells expressing CD8 phenotype (CD8 Treg cells) in MM. To the best of our knowledge, this has not been reported previously in MM. Methods: We analyzed CD8 Treg cells and their transcription factor FoxP3 from 64 newly diagnosed MM patients using flow cytometry and real time-polymerase chain reaction (RT-PCR). RNA profile of cytokines in CD8 Treg cells was also assessed using RT-PCR. CD8 Treg cells from 5 MM patients and 5 healthy donors were functionally evaluated using proliferation