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further evidence supporting a role for gs signal transduction in severe malaria pathogenesis进一步的证据支持gs信号转导的作用严重疟疾发病机理
Further Evidence Supporting a Role for Gs Signal
Transduction in Severe Malaria Pathogenesis
1,2 1 2 1,2 1
Sarah Auburn *, Andrew E. Fry , Taane G. Clark , Susana Campino , Mahamadou Diakite , Angela
1 1 3 3 3
Green , Anna Richardson , Muminatou Jallow , Fatou Sisay-Joof , Margaret Pinder , Malcolm E.
4,5 6,7 8 1,2 1,2
Molyneux , Terrie E. Taylor , Kasturi Haldar , Kirk A. Rockett , Dominic P. Kwiatkowski
1 Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, 2 Wellcome Trust Sanger Institute, Hinxton, United Kingdom, 3 Medical Research Council, Banjul,
The Gambia, 4 The Malawi-Liverpool-Wellcome Trust Programme of Clinical Tropical Research, College of Medicine, Blantyre, Malawi, 5 Liverpool School of Tropical
Medicine, Pembroke Place, Liverpool, United Kingdom, 6 Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi, 7 Department of Internal
Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America, 8 Center for Rare and Neglected Diseases,
University of Notre Dame, South Bend, Indiana, United States of America
Abstract
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the
aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge,
the stimulatory G protein (Gs) sig
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