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genetic and infectious profiles of japanese multiple sclerosis patients遗传和传染性的日本多发性硬化症患者.pdf

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genetic and infectious profiles of japanese multiple sclerosis patients遗传和传染性的日本多发性硬化症患者

Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients 1. 1. 1 2 1 Satoshi Yoshimura , Noriko Isobe , Tomomi Yonekawa , Takuya Matsushita , Katsuhisa Masaki , 1 3 4 1 Shinya Sato , Yuji Kawano , Ken Yamamoto , Jun-ichi Kira *, the South Japan Multiple Sclerosis Genetics Consortium 1 Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2 Department of Clinical Neuroimmunology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 3 Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, 4 Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan Abstract Background: Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS in Japanese patients. Methodology/Principal Findings: We analyzed HLA-DRB1 and -DPB1 alleles, and IgG antibodies specific for Helicobacter pylori, Chlamydia pneumoniae, varicella zoster virus, and Epstein-Barr virus nuclear antigen (EBNA) in 145 MS patients and 367 healthy controls (HCs). Frequencies of DRB1*040