genetic determinants of human health span and life span progress and new opportunities遗传因素人类健康跨度和寿命进展和新的机遇.pdfVIP

Review Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities * George M. Martin , Aviv Bergman, Nir Barzilai ABSTRACT Second, while we have learned a great deal about developmental biology from worms, flies, and mice, there is a e review three approaches to the genetic analysis paucity of detailed information on the pathophysiology of W of the biology and pathobiology of human aging. aging and of their variations among genetically heterogeneous The first and so far the best-developed is the wild-type populations, particularly in worms and flies. In search for the biochemical genetic basis of varying contrast, there is a vast literature on these and all other aspects susceptibilities to major geriatric disorders. These include a of human biology, including remarkable progress in human range of progeroid syndromes. Collectively, they tell us much genetics (Table 1). Moreover, physicians have provided about the genetics of health span. Given that the major risk detailed characterizations of late-life disabilities and diseases factor for virtually all geriatric disorders is biological aging, in human populations (Table 2). Third, additional and unique they may also serve as markers for the study of intrinsic DNA sequences have evolved in Homo sapiens, including rapidly biological aging. The second approach seeks to identify allelic evolving functionally significant intronic sequences that contributions to exceptionally long life spans. While linkage distinguish us from our nearest relative, the common to a locus on Chromos