genetic determinants of time perception mediated by the serotonergic system遗传决定因素的时间知觉的血清素激活的系统.pdfVIP
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genetic determinants of time perception mediated by the serotonergic system遗传决定因素的时间知觉的血清素激活的系统
Genetic Determinants of Time Perception Mediated by
the Serotonergic System
1 2 ˇ ´ 3
Olga V. Sysoeva *, Alexander G. Tonevitsky , Jirı Wackermann
1 Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia, 2 Russian Research Institute of Sport and Physical Education,
Moscow, Russia, 3 Institute for Frontier Areas of Psychology and Mental Health, Freiburg im Breisgau, Germany
Abstract
Background: The present study investigates neurobiological underpinnings of individual differences in time perception.
Methodology: Forty-four right-handed Russian Caucasian males (18–35 years old) participated in the experiment. The
polymorphism of the genes related to the activity of serotonin (5-HT) and dopamine (DA)-systems (such as 5-HTT, 5HT2a,
MAOA, DAT, DRD2, COMT) was determined upon the basis of DNA analysis according to a standard procedure. Time
perception in the supra-second range (mean duration 4.8 s) was studied, using the duration discrimination task and
parametric fitting of psychometric functions, resulting in individual determination of the point of subjective equality (PSE).
Assuming the ‘dual klepsydra model’ of internal duration representation, the PSE values were transformed into equivalent
values of the parameter k (kappa), which is a measure of the ‘loss rate’ of the duration representation. An association
between time representation parameters (PSE and k, respectively) and 5-HT-related genes was found, but not with DA-
related genes. Higher ‘loss rate’ (k) of the cumulative duration representation were found for the carriers of genotypes
characterized by higher 5-HT transmission, i.e., 1) lower 5-HT reuptake, known for the 5-HTTLPR SS polymorphism compared
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