genetic differences between the determinants of lipid profile phenotypes in african and european americans the jackson heart study遗传差异的决定因素血脂表型在非洲和欧洲的美国人杰克逊心脏研究.pdfVIP

Genetic Differences between the Determinants of Lipid Profile Phenotypes in African and European Americans: The Jackson Heart Study 1,2,3 1,4 1 5,6 1,4 Rahul C. Deo *, David Reich , Arti Tandon , Ermeg Akylbekova , Nick Patterson , Alicja 4 2,3,4 6 5,6,7 5,8 Waliszewska , Sekar Kathiresan , Daniel Sarpong , Herman A. Taylor, Jr. , James G. Wilson * 1 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, 5 Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America, 6 Jackson State University, Jackson, Mississippi, United States of America, 7 Tougaloo College, Tougaloo, Mississippi, United States of America, 8 G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America Abstract Genome-wide association analysis in populations of European descent has recently found more than a hundred genetic variants affecting risk for common disease. An open question, however, is how relevant the variants discovered in Europeans are to other populations. To address this problem