genetic diversity in new members of the reticulocyte binding protein family in thai plasmodium vivax isolates遗传多样性在网织红细胞结合蛋白家族的新成员在泰国间日疟原虫隔离.pdfVIP
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genetic diversity in new members of the reticulocyte binding protein family in thai plasmodium vivax isolates遗传多样性在网织红细胞结合蛋白家族的新成员在泰国间日疟原虫隔离
Genetic Diversity in New Members of the Reticulocyte
Binding Protein Family in Thai Plasmodium vivax Isolates
1,2 1 3 ¨ 3 3
Varakorn Kosaisavee , Usa Lek-Uthai , Rossarin Suwanarusk , Anne Charlotte Gruner , Bruce Russell ,
4,5 ´ 2 6,7
Francois Nosten , Laurent Renia , Georges Snounou *
1 Department of Parasitology and Entomology, Faculty of Public Health, Mahidol University, Bangkok, Thailand, 2 Doctor of Public Health Programme (Parasitology),
Faculty of Graduate Studies, Mahidol University, Nakornpathom, Thailand, 3 Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis,
Singapore, 4 Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand, 5 Center for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom, 6 Institut National de
´ ´ ´ ´ ´ ´ ´ ˆ `
la Sante et de la Recherche Medicale, Unite Mixte de Recherche S 665, Paris, France, 7 Universite Pierre Marie Curie, Faculte de Medecine Pitie-Salpetriere, Paris, France
Abstract
Background: Plasmodium vivax merozoites specifically invade reticulocytes. Until recently, two reticulocyte-binding proteins
(Pvrbp1 and Pvrbp2) expressed at the apical pole of the P. vivax merozoite were considered to be involved in reticulocyte
recognition. The genome sequence recently obtained for the Salvador I (Sal-I) strain of P. vivax revealed additional genes in
this family, and in particular Pvrbp2a, Pvrbp2b (Pvrbp2 has been renamed as Pvrbp2c) and two pseudogenes Pvrbp2d and
Pvrbp3. It had been previously f
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