genetic diversity of staphylocoagulase genes (coa) insight into the evolution of variable chromosomal virulence factors in staphylococcus aureusstaphylocoagulase基因的遗传多样性(coa)洞察变量染色体进化的金黄色葡萄球菌毒力因素.pdfVIP

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genetic diversity of staphylocoagulase genes (coa) insight into the evolution of variable chromosomal virulence factors in staphylococcus aureusstaphylocoagulase基因的遗传多样性(coa)洞察变量染色体进化的金黄色葡萄球菌毒力因素.pdf

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genetic diversity of staphylocoagulase genes (coa) insight into the evolution of variable chromosomal virulence factors in staphylococcus aureusstaphylocoagulase基因的遗传多样性(coa)洞察变量染色体进化的金黄色葡萄球菌毒力因素

Genetic Diversity of Staphylocoagulase Genes (coa): Insight into the Evolution of Variable Chromosomal Virulence Factors in Staphylococcus aureus 1¤a 1,2 1 1 3 1¤b Shinya Watanabe , Teruyo Ito *, Takashi Sasaki , Shanshuang Li , Ikuo Uchiyama , Kozue Kishii , 1,2 4 1,2 Ken Kikuchi , Robert Leo Skov , Keiichi Hiramatsu 1 Department of Infection Control Science, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan, 2 Department of Bacteriology, School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan, 3 National Institute for Basic Biology, National Institutes of Natural Sciences, Myodaiji, Okazaki, Japan, 4 National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark Abstract Background: The production of staphylocoagulase (SC) causing the plasma coagulation is one of the important characteristics of Staphylococcus aureus. Although SCs have been classified into 10 serotypes based on the differences in the antigenicity, genetic bases for their diversities and relatedness to chromosome types are poorly understood. Methodology/Principal Findings: We compared the nucleotide sequences of 105 SC genes (coa), 59 of which were determined in this study. D1 regions, which contain prothrombin-activating and -binding domains and are presumed to be the binding site of each type-specific antiserum, were classified into twelve clusters having more than 90% nucleotide identities, resulting to create two novel SC types, XI and XII, in addition to extant 10