genetic engineering of trypanosoma (dutonella) vivax and in vitro differentiation under axenic conditions基因工程的锥虫属(dutonella)间日疟原虫和无菌条件下体外分化.pdfVIP

genetic engineering of trypanosoma (dutonella) vivax and in vitro differentiation under axenic conditions基因工程的锥虫属(dutonella)间日疟原虫和无菌条件下体外分化.pdf

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genetic engineering of trypanosoma (dutonella) vivax and in vitro differentiation under axenic conditions基因工程的锥虫属(dutonella)间日疟原虫和无菌条件下体外分化

Genetic Engineering of Trypanosoma (Dutonella) vivax and In Vitro Differentiation under Axenic Conditions 1 1 1 1,2 3 Simon D’Archivio , Mathieu Medina , Alain Cosson , Nathalie Chamond , Brice Rotureau , Paola Minoprio1*, Sophie Goyard1 ` 1 Laboratoire des Processus Infectieux a Trypanosoma, Department of Infection and Epidemiology, Paris, France, 2 Laboratoire de Cristallographie et RMN Biologiques - ´ ´ Universite Paris Descartes France, CNRS UMR 8015, Paris, France, 3 Unite de Biologie Cellulaire des Trypanosomes, CNRS URA 2581, Department of Parasitology, Paris, France Abstract Trypanosoma vivax is one of the most common parasites responsible for animal trypanosomosis, and although this disease is widespread in Africa and Latin America, very few studies have been conducted on the parasite’s biology. This is in part due to the fact that no reproducible experimental methods had been developed to maintain the different evolutive forms of this trypanosome under laboratory conditions. Appropriate protocols were developed in the 1990s for the axenic maintenance of three major animal Trypanosoma species: T. b. brucei, T. congolense and T. vivax. These pioneer studies rapidly led to the successful genetic manipulation of T. b. brucei and T. congolense. Advances were made in the understanding of these parasites’ biology and virulence, and new drug targets were identified. By contrast, challenging in vitro conditions have been developed for T. vivax in the past, and this per se has contributed

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