genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations基因的影响与后果多向性的位点是上下文相关的维护种群的遗传变异.pdfVIP

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genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations基因的影响与后果多向性的位点是上下文相关的维护种群的遗传变异.pdf

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genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations基因的影响与后果多向性的位点是上下文相关的维护种群的遗传变异

Genetic Effects at Pleiotropic Loci Are Context- Dependent with Consequences for the Maintenance of Genetic Variation in Populations 1 1 1 2 1 Heather A. Lawson *, Janet E. Cady , Charlyn Partridge , Jason B. Wolf , Clay F. Semenkovich , James M. Cheverud1 1 Washington University in St Louis, St Louis, Missouri, United States of America, 2 University of Bath, Bath, United Kingdom Abstract Context-dependent genetic effects, including genotype-by-environment and genotype-by-sex interactions, are a potential mechanism by which genetic variation of complex traits is maintained in populations. Pleiotropic genetic effects are also thought to play an important role in evolution, reflecting functional and developmental relationships among traits. We examine context-dependent genetic effects at pleiotropic loci associated with normal variation in multiple metabolic syndrome (MetS) components (obesity, dyslipidemia, and diabetes-related traits). MetS prevalence is increasing in Western societies and, while environmental in origin, presents substantial variation in individual response. We identify 23 pleiotropic MetS quantitative trait loci (QTL) in an F16 advanced intercross between the LG/J and SM/J inbred mouse strains (Wustl:LG,SM-G16; n = 1002). Half of each family was fed a high-fat diet and half fed a low-fat diet; and additive, dominance, and parent-of-origin imprinting genotypic effects were examined in animals partitioned into sex, diet, and sex-by-diet cohorts. We examine the context-dependency of the underlying additive, dominance, and imprinting genetic effects of the traits associated with these pleiotropic QTL. Further, we examine sequence polymorphisms (SNPs) between