genome-wide transcriptional response of silurana (xenopus) tropicalis to infection with the deadly chytrid fungus全基因组转录反应silurana(非洲爪蟾蜍)tropicalis感染致命的壶菌.pdfVIP

Genome-Wide Transcriptional Response of Silurana (Xenopus) tropicalis to Infection with the Deadly Chytrid Fungus 1,2 1 3 4 5 Erica Bree Rosenblum *, Thomas J. Poorten , Matthew Settles , Gordon K. Murdoch , Jacques Robert , Nicole Maddox2, Michael B. Eisen2,6 1 Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America, 2 Departments of Molecular and Cell Biology and Integrative Biology, University of California, Berkeley, California, United States of America, 3 School of Molecular Bioscience and Department of Animal Sciences, Washington State University, Pullman, Washington, United States of America, 4 Department of Animal and Veterinary Science, University of Idaho, Moscow, Idaho, United States of America, 5 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America, 6 Howard Hughes Medical Institute, University of California, Berkeley, California, United States of America Abstract Emerging infectious diseases are of great concern for both wildlife and humans. Several highly virulent fungal pathogens have recently been discovered in natural populations, highlighting the need for a better understanding of fungal-vertebrate host-pathogen interactions. Because most fungal pathogens are not fatal in the absence of other predisposing conditions, host-pathogen dynamics for deadly fungal pathogens are of particular interest. The chytrid fungus Batrachochytrium dendrobatidis (hereafter Bd) infects hundreds of species of frogs in the wild. It is found worldwide and is a significant contributor to the current global amphibian decline. However, the mechanism by which Bd causes de