green tea polyphenols rescue of brain defects induced by overexpression of dyrk1a绿茶多酚救援dyrk1a大脑过度引起的缺陷.pdfVIP

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green tea polyphenols rescue of brain defects induced by overexpression of dyrk1a绿茶多酚救援dyrk1a大脑过度引起的缺陷.pdf

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green tea polyphenols rescue of brain defects induced by overexpression of dyrk1a绿茶多酚救援dyrk1a大脑过度引起的缺陷

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A 1 ´ ´ 2 3 1 1 4 Fayc¸al Guedj , Catherine Sebrie , Isabelle Rivals , Aurelie Ledru , Evelyne Paly , Jean C. Bizot , 5 6 2 7 1 Desmond Smith , Edward Rubin , Brigitte Gillet , Mariona Arbones , Jean M. Delabar * ´ 1 Functional and Adaptive Biology, Universite Paris Diderot-Paris7 and CNRS, Paris, France, 2 Laboratoire de RMN Biologique, ICSN-CNRS, Gif sur Yvette, France, 3 Equipe ´ de Statistique Appliquee, ESPCI, Paris, France, 4 Key-Obs SA, Parc Technologique de La Source, Orleans, France, 5 Department of Molecular and Medical Pharmacology, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America, 6 Genome Sciences Department, Lawrence Berkeley National Lab (LBNL), Berkeley, California, United States of America, 7 Center for Genomic Regulation, Universitat Pompeu Fabra (UPF), Barcelona, Spain Abstract Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume