haplotype distribution and evolutionary pattern of mir-17 and mir-124 families based on population analysis单体型分布和进化mir - 17和mir - 124的家庭模式基于人口分析.pdfVIP

Haplotype Distribution and Evolutionary Pattern of miR- 17 and miR-124 Families Based on Population Analysis 1 1 2 1 1,2 Li Guo , Beili Sun , Fei Sang , Wei Wang , Zuhong Lu * 1 State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China, 2 Key Laboratory of Child Development and Learning Science of Ministry of Education, Southeast University, Nanjing, China Abstract Background: MicroRNAs (miRNAs) are small, endogenously expressed non-coding RNAs that regulate mRNAs post- transcriptionally. Previous studies have explored miRNA evolutionary trend, but evolutionary history and pattern in the miRNA world are still not fully clear. In the paper, we intended to analyze miRNA haplotype distribution and evolutionary network by analyzing miRNA sequences of miR-17 and miR-124 families across animal species as special populations. Principal Findings: 31 haplotypes were detected in miR-17 family while only 9 haplotypes were defined in miR-124 family. The complex miR-17 family was mainly distributed in vertebrates, but miR-124 was shared by more animal species from Caenorhabditis to Homo and had a wide distribution spectrum. Some haplotypes of the two miRNA families appeared discontinuous distributions across animals. Compared with a simple phylogenetic network in miR-124 family, miR-17 family indicated a complex network with some median vectors that might be lost ancestral or potential miRNA haplotypes. By analyzing different miRNAs across 12 animal species, we found these small RNAs showed different haplotype diversities, haplotype distributions and phylogenetic networks. Conclusions: Different miRNAs had quite different haplo