high genetic diversity among community-associated staphylococcus aureus in europe results from a multicenter study遗传多样性很高community-associated金黄色葡萄球菌在欧洲多中心研究的结果.pdfVIP

High Genetic Diversity among Community-Associated Staphylococcus aureus in Europe: Results from a Multicenter Study 1 1 2 2 1,3 1 Joana Rolo , Maria Miragaia , Agata Turlej-Rogacka , Joanna Empel , Ons Bouchami , Nuno A. Faria , 1 2 4 ´ 1,5 Ana Tavares , Waleria Hryniewicz , Ad C. Fluit , Hermınia de Lencastre *, and the CONCORD Working Group ´ ´ 1 Laboratory of Molecular Genetics, Instituto de Tecnologia Quımica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal, 2 National Medicines Institute, Division of Clinical Microbiology and Infection Prevention, Warsaw, Poland, 3 Laboratory of the National Bone Marrow Transplantation Centre, Bab Saadoun, Tunis, Tunisia, 4 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands, 5 Laboratory of Microbiology, The Rockefeller University, New York, New York, United States of America Abstract Background: Several studies have addressed the epidemiology of community-associated Staphylococcus aureus (CA-SA) in Europe; nonetheless, a comprehensive perspective remains unclear. In this study, we aimed to describe the population structure of CA-SA and to shed light on the origin of methicillin-resistant S. aureus (MRSA) in this continent. Methods and Findings: A total of 568 colonization and infection isolates, comprising both MRSA and methicillin-susceptible S. aureus (MSSA), were recovered in 16 European countries, from community and community-onset infection