high prevalence of vitamin d deficiency in pregnant women a national cross-sectional survey高度流行的维生素d缺乏孕妇一个全国性的横断面调查.pdfVIP

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high prevalence of vitamin d deficiency in pregnant women a national cross-sectional survey高度流行的维生素d缺乏孕妇一个全国性的横断面调查.pdf

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high prevalence of vitamin d deficiency in pregnant women a national cross-sectional survey高度流行的维生素d缺乏孕妇一个全国性的横断面调查

High Prevalence of Vitamin D Deficiency in Pregnant Women: A National Cross-Sectional Survey 1 2 1 2 Stefanie Vandevijvere *, Sihame Amsalkhir , Herman Van Oyen , Rodrigo Moreno-Reyes ˆ ´ 1 Department of Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium, 2 Department of Nuclear Medicine, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium Abstract An increasing number of studies suggest that vitamin D deficiency during pregnancy is associated with multiple adverse health outcomes in mothers, neonates and children. There are no representative country data available on vitamin D status of pregnant women in Europe. The aim of this study was to estimate the prevalence of vitamin D deficiency among Belgian pregnant women and to assess the determinants of vitamin D status in the first and third trimester of pregnancy. The women were selected via a multi-stage proportionate-to-size sampling design. Blood samples were collected and a questionnaire was completed face-to-face. 55 obstetric clinics were randomly selected and 1311 pregnant women participated in the study. The median serum 25-hydroxyvitamin D [25-(OH)D] concentration was significantly lower in the first trimester (20.4 ng/ml) than in third trimester (22.7 ng/ml). Of all women, 74.1% (95%CI = 71.8–76.5%) were vitamin D insufficient (25-(OH)D ,30 ng/ml), 44.6% (95%CI = 41.9–47.3%) were vitamin D deficient (25-(OH)D ,20 ng/ml), while 12.1% (95%CI = 10.3–13.8%) were