high prevalence of vitamin d insufficiency in china relationship with the levels of parathyroid hormone and markers of bone turnover在中国盛行的维生素d不足与甲状旁腺素的水平和骨代谢标志物.pdfVIP

High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover 1. 2,3. 2 2 2 3 Han-Kui Lu , Zeng Zhang , Yao-Hua Ke , Jin-Wei He , Wen-Zhen Fu , Chang-Qing Zhang , Zhen- Lin Zhang2* 1 Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, 2 Metabolic Bone Disease and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, 3 Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Abstract There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross- sectional study involved 649 men and 1939 women aged 20–89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (,30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (,20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as ,10, 10–20, 20–30, and $30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p,0.001). There was an inverse relationship b