high γ-radiation sensitivity is associated with increased gastric cancer risk in a chinese han population a case-control analysis高γ-radiation敏感性与胃癌风险增加有关在中国汉族人群病例对照分析.pdfVIP

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high γ-radiation sensitivity is associated with increased gastric cancer risk in a chinese han population a case-control analysis高γ-radiation敏感性与胃癌风险增加有关在中国汉族人群病例对照分析.pdf

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high γ-radiation sensitivity is associated with increased gastric cancer risk in a chinese han population a case-control analysis高γ-radiation敏感性与胃癌风险增加有关在中国汉族人群病例对照分析

High c-Radiation Sensitivity Is Associated with Increased Gastric Cancer Risk in a Chinese Han Population: A Case- Control Analysis 1. 2. 1 1 3 4 3 Honglin Dong , Xiaowei Jin , Jie Hu , Haifeng Li , Xianli He , Xiaonan Liu *, Guoqiang Bao * 1 Department of General Surgery, Second Hospital, Shanxi Medical University. Taiyuan, China, 2 Department of Digestive Diseases, General Hospital of Air Forces of PLA, Beijing, China, 3 Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China, 4 Xijing Hospital of Digestive Disease, The Fourth Military Medical University, Xi’an, China Abstract Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of several malignancies, but not including gastric cancer. In this case-control study, radiation sensitivity as measured by chromatid breaks per cell (b/ c) was examined in cultured peripheral blood lymphocytes (PBLs) from 517 patients with gastric cancer and 525 healthy controls. Our results showed that b/c values were significantly higher in cases than in controls (Mean [SD], 0.47 [0.20] vs. 0.34 [0.17]; P,0.001). Using the 50th percentile value for controls (0.34 b/c) as the cutoff point, unconditional logistic regression analysis revealed that c–radiation-sensitive individuals were at significantly higher risk for gastric cancer (adjusted odds ratio [OR] 2.01, 95% confidence interval [CI] 1.49–3.13). Quartile stratification analysis indicated a dose-response relationship between c-radiation sensitivity and gastric cancer risk (P for trend ,0.001). When using the subjects in first quartile of b/c values as reference, the adjusted ORs and corresponding CIs for the subjects in second, third, and fourth quartil