high-resolution mapping of gene expression using association in an outbred mouse stock高分辨率远系繁殖基因表达使用协会的映射鼠标股票.pdfVIP

High-Resolution Mapping of Gene Expression Using Association in an Outbred Mouse Stock 1 1 1,2 3 3 1 Anatole Ghazalpour *, Sudheer Doss , Hyun Kang , Charles Farber , Ping-Zi Wen , Alec Brozell , Ruth 1 1,2 4 5,6 1,3,6,7 Castellanos , Eleazar Eskin , Desmond J. Smith , Thomas A. Drake , Aldons J. Lusis 1 Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America, 2 Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America, 3 Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 4 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 5 Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 6 Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America, 7 Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America Abstract Quantitative trait locus (QTL) analysis is a powerful tool for mapping genes for complex traits in mice, but its utility is limited by poor resolution. A promising mapping approach is association analysis in outbred stocks or different inbred strains. As a proof of concept for the association