high-throughput analysis of synthetic peptides for the immunodiagnosis of canine visceral leishmaniasis高通量分析,合成肽的免疫诊断犬内脏利什曼病.pdfVIP
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high-throughput analysis of synthetic peptides for the immunodiagnosis of canine visceral leishmaniasis高通量分析,合成肽的免疫诊断犬内脏利什曼病
High-Throughput Analysis of Synthetic Peptides for the
Immunodiagnosis of Canine Visceral Leishmaniasis
´ 1 ´ 2 ´ 2 3 2
Angelica R. Faria , Mıriam M. Costa , Mario S. Giusta , Gabriel Grimaldi Jr. , Marcus L. O. Penido ,
2,4,5 ´ 1
Ricardo T. Gazzinelli , Helida M. Andrade *
ˆ ´ ´
1 Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil, 2 Departamento de Bioquımica e
ˆ ´ ˜
Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil, 3 Instituto Oswaldo Cruz – Fundac¸ao Oswaldo Cruz, Rio de
´ ˜
Janeiro, Brasil, 4 Centro de Pesquisas Rene Rachou – Fundac¸ao Oswaldo Cruz, Belo Horizonte, Brasil, 5 Division of Infectious Diseases and Immunology, University of
Massachusetts Medical School, Worcester, Massachusetts, United States of America
Abstract
Background: Visceral leishmaniasis is the most severe form of leishmaniasis. Approximately 20% of zoonotic human visceral
leishmaniasis worldwide is caused by Leishmania infantum, which is also known as Leishmania chagasi in Latin America, and
disease incidence is increasing in urban and peri-urban are
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