human monoclonal antibody combination against sars coronavirus synergy and coverage of escape mutants人类单克隆抗体结合对sars冠状病毒协同和逃避突变体的报道.pdfVIP
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human monoclonal antibody combination against sars coronavirus synergy and coverage of escape mutants人类单克隆抗体结合对sars冠状病毒协同和逃避突变体的报道
PLoS MEDICINE
Human Monoclonal Antibody Combination
against SARS Coronavirus: Synergy
and Coverage of Escape Mutants
1[* 1[ 2 1 2
Jan ter Meulen , Edward N. van den Brink , Leo L. M. Poon , Wilfred E. Marissen , Cynthia S. W. Leung ,
1 2 1 1 1 3
Freek Cox , Chung Y. Cheung , Arjen Q. Bakker , Johannes A. Bogaards , Els van Deventer , Wolfgang Preiser ,
3 4 1 2 1
Hans Wilhelm Doerr , Vincent T. Chow , John de Kruif , Joseph S. M. Peiris , Jaap Goudsmit
1 Crucell Holland B.V., Leiden, Netherlands, 2 Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of
the People’s Republic of China, 3 Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany, 4 Department of Microbiology, Yong Loo
Lin School Faculty of Medicine, National University of Singapore, Singapore
Funding: This work was in part A B S T R A C T
supported by EU STREP grant SP22-
CT2004–511064, SenterNovem grant
TSGE2006 and grant AI95357 from Background
the National Institute of Allergy and
Infectious Disease. The funders had Experimental animal data show that protection against severe acute respiratory syndrome
no role in study design, data
collection and analysis, decision to coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasib
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