human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke人类神经祖细胞移植增加大脑的神经发生和小胶质招聘有中风的老鼠.pdfVIP

human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke人类神经祖细胞移植增加大脑的神经发生和小胶质招聘有中风的老鼠.pdf

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human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke人类神经祖细胞移植增加大脑的神经发生和小胶质招聘有中风的老鼠

Human Neural Progenitor Cell Engraftment Increases Neurogenesis and Microglial Recruitment in the Brain of Rats with Stroke 1 1 1 2 2 2 Zahra Hassani , Joanna O’Reilly , Yewande Pearse , Paul Stroemer , Ellen Tang , John Sinden , 1 1 Jack Price *, Sandrine Thuret * 1 Centre for the Cellular Basis of Behaviour, The James Black Centre, King’s College London, Institute of Psychiatry, London, United Kingdom, 2 ReNeuron Group plc, Guildford, Surrey, United Kingdom Abstract Main Objectives: Stem cell transplantation is to date one of the most promising therapies for chronic ischemic stroke. The human conditionally immortalised neural stem cell line, CTX0E03, has demonstrable efficacy in a rodent model of stroke and is currently in clinical trials. Nonetheless, the mechanisms by which it promotes brain repair are not fully characterised. This study investigated the cellular events occurring after CTX0E03 transplantation in the brains of rats that underwent ischemic stroke. Methods: We focused on the endogenous proliferative activity of the host brain in response to cell transplantation and determined the identity of the proliferating cells using markers for young neurons (doublecortin, Dcx) and microglia (CD11b). So as to determine the chronology of events occurring post-transplantation, we analysed the engrafted brains one week and four weeks post-transplantation. Results: We observed a significantly greater endogenous proliferation in the striatum of ischemic brains receiving a CTX0E03 graft compared to vehicle-treated ischemic brains. A significant proportion of these proliferative cells were found to be Dcx+ striatal neuroblasts. Further, we describe an

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