mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma突变斑马鱼lrp2导致成人眼青光眼发病机理模型近视和其他风险因素.pdfVIP

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2017-09-01 发布于上海
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mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma突变斑马鱼lrp2导致成人眼青光眼发病机理模型近视和其他风险因素.pdf

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mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma突变斑马鱼lrp2导致成人眼青光眼发病机理模型近视和其他风险因素

Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma 1 2 1 1 2 Kerry N. Veth , Jason R. Willer , Ross F. Collery , Matthew P. Gray , Gregory B. Willer , Daniel S. 3 4 5 6 6 2 Wagner , Mary C. Mullins , Ava J. Udvadia , Richard S. Smith , Simon W. M. John , Ronald G. Gregg , Brian A. Link1* 1 Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, 2 Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America, 3 Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America, 4 Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America, 5 Department of Biological Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, United States of America, 6 Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine, United States of America Abstract The glaucomas comprise a genetically complex group of retinal neuropathies that typically occur late in life and are characterized by progressive pathology of the optic nerve head and degeneration of retinal ganglion cells. In addition to age and family history, other significant risk factors for glaucoma include elevated intraocular pressure (IOP) and myopia. The complexity of glaucoma has made it difficult to model in animals, but also challenging to identify responsible genes. We have used zebrafish to identify a genetically complex,