慢型克山病与扩张型心肌病患者抗氧化能力对比研究-newcentury.pdf

/index.php/gjph Global Journal of Public Health, 2015, Vol.2, No.1 The comparative study on antioxidant capacity of Keshan disease and dilated cardiomyopathy patients Wang Xiuhong, Wang Jing, Wang Yuanyuan, Zhang Wenming, Liu Yuan Shandong Institute of Prevention and Treatment of Endemic Disease, Jinan Shandong, China Received: Nov 26, 2014 Accepted: Dec 21, 2014 Published: Apr 25, 2015 DOI: 10.14725/gjph.v2n1a944 URL: /10.14725/gjph.v2n1a944 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Objective: To compare the serum levels of selenium, selenoprotein and malondialdehyde about Keshan disease (KSD) and dilated cardiomyopathy (DCM) patients and to investigate the relationship between the antioxidant capacity and myocardial injury. Methods: 26 KSD patients, 18 DCM patients, 24 healthy people in KSD areas and 22 healthy people in non-KSD areas were selected by all-round physical examination and electrocardiography. Blood samples were collected by informing consent and volunteering. The serum selenium was determined by using 2,3 - two amino-naphthalene fluorescence method. The serum selenoprotein and malondialdehyde were measured by using biotin double-antibody sandwich method of enzyme linked immunosorbent assay (ELISA) (according to kit instructions). Results: There were no statistical differences about the distribution of the gender and age in every subjects’ groups (P ＞0.05). The levels of serum selenium and selenoprotein in Keshan disease group and dilated cardiomyopathy group were significantly lower than those of healthy group whether in KSD areas or in non- KSD areas , and the serum malondialdehyde were higher than those in healthy controls. There were no statist