男性糖化血红蛋白水平与高血压发病风险研究-中华老年多器官疾病杂志.doc

·临床研究· 男性糖化血红蛋白水平与高血压发病风险研究 姚秀萍*，王爱英2*，高凌根2 （1武警总医院保健科，北京 100039；2解放军总医院南楼临床部综合外科，北京 100853） 【摘 要】目的 日本TOPICS16研究表明更高的空腹血糖预测高血压发生的风险，而糖化血红蛋白则无预测作用。本研究的目的是了解基础糖化血红蛋白水平是否与高血压发病相关。方法 入选4 586名尚未诊断高血压病、糖尿病及心脑血管疾病的男性体检人员，收集其基线临床资料，并分析糖化血红蛋白水平与高血压发病的关系。结果 经过11.5年随访，2027（44.2%）人患高血压，经校正传统的心血管疾病危险因素后，五分位糖化血红蛋白水平从低（＜4.75%）至高（≥5.18%）与高血压发病风险值分别为1.0（参考值），0.99（0.93，1.07）1.06（0.99，1.14）1.08（1.02，1.15）1.22（1.171.35）4.7mmol/L；4.8?5.2mmol/L；5.3?5.7mmol/L；≥5.7mmol/L）分组，经校正传统的心血管疾病危险因素后，空腹血糖＜4.7mmol/L组高血压发病风险比值参考值为1，可发现按血糖水平按由低到高的顺序其高血压发病风险比值分别为0.95（0.92，1.05）0.96（0.91，1.06），1.01（0.95，1.10 未患糖尿病男性的糖化血红蛋白水平与高血压发病相关。 【关键词】糖化血红蛋白；葡萄糖代谢；高血压 【中图分类号】 R544.1 【文献标识码】 A 【DOI】 10.11915/j.issn.1671-5403.2015.xx.xxx Correlation of hemoglobin A1c and risk of hypertension in men YAO Xiu-Ping1*, WANG Ai-Ying2*, GAO Ling-Gen2 (1Health Service Office, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China; 2Department of Geriatric Surgery, Chinese PLA General Hospital, Beijing 100853, China) 【Abstract】 Objective The Toranomon Hospital Health Management Center Study 16 (TOPICS 16) showed that higher fasting plasma glucose (FPG) indicated increased risk of hypertension, but glycosylated hemoglobin A1c (HbA1c) did not. This study aimed to investigate whether HbA1c was associated with the risk of hypertension. Methods A prospective study was carried out on 4 586 men initially free of hypertension, diabetes, and cardiovascular disease who taking regular physical examination in our hospital to assess the relationship of baseline HbA1c with hypertension. Their baseline clinical data were collected. The quintiles and clinical cutpoints of HbA1c for the risk of hypertension were considered and analyzed. Results During a median follow-up of 11.5 years, 2 027 of the cohort (44.2%) developed hypertension. In the model adjusted for traditional cardiovascular risk factors, the hazard ratios (HR) from the lowest (＜4.75 %) to the highest (≥5.18%) quintile of HbA1c were 1