标准石英粉尘及青石棉直接诱导8羟基脱氧鸟苷加合物-环境科学学报.PDF

标准石英粉尘及青石棉直接诱导8羟基脱氧鸟苷加合物-环境科学学报.PDF

  1. 1、本文档共5页,可阅读全部内容。
  2. 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
标准石英粉尘及青石棉直接诱导8羟基脱氧鸟苷加合物-环境科学学报

21 4 Vol. 21, No.4 2001 7 ACTA SCIENTIAE CIRCUMSTANTIAE July, 2001 :2001 : R9946 :A 8 袭著革, 晁福寰, 孙咏梅, 杨丹凤, 张华山, 刘中文 ( , 300050) : , DNA 8 . , DNA 8, ; H O DNA . , ; 2 2 DNA 8. : ; ; DNA ;8; Study on the formation of 8hydroxy2 deoxyguanosine adduct directly induced by standard silicon dust and crocidolite XI Zhuge, CHAO Fuhua , SUN Yo gmei, YANG Da fe g, ZHANG Huasha , LIU Zho gwe ( I stitute of health a d e viro me tal medici e, academy of military medical scie ces,Tia ji 300050) Abstract:The formatio a dmecha ism of oxidative DNA damage marker8hydroxy2deoxygua osi e, i duced by sta dard silico dust a d crocidolite i vitro, were discussed usi g high performa ce liquid chromatograph coupled with electrochemical detectio . The results showed that sta dard silico dust a d crocidolit fibers cause DNA oxidative damage to form 8hydroxy2deoxygua osi e; but the effect i duced by crocidolit fibers is sro ger tha by sta dard silico dust. The catalytic ability of H O oxidizi g DNA by sta dard silico dust is sighifica tly 2 2 differe t from tha t by crocidolit fibers. Both possece direct ge otoxicity. To i duce DNA formi g stro gly mutage tic 8hydroxy2deox ygua osi e is o e of the possible mecha ism of their pote tial carci oge sis. Keywords: sta dard silico dust; crocidolit; oxidative DNA damage; 8hydroxy2deoxygua osi e; HPLCECD ( SiO ) , , 2 [ 1] , ( IARC) , [2] . ( Na2 O!Fe2O3 !3FeO!8SiO2 !H2O) . , DNA

您可能关注的文档

文档评论(0)

xiaozu + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档