IUGR模型的应用-中国试验动物学报.DOC

胎儿宫内发育迟缓(IUGR)动物模型研究进展 金慧慧，赵永聚* （西南大学动物科技学院，重庆市牧草与草食家畜重点实验室，重庆市草食动物资源保护与利用工程技术研究中心，重庆 北碚 400716） 摘要：胎儿宫内发育迟缓Intrauterine growth restriction，IUGR是一种危害胎儿生存质量的严重并发症，建立与人类临床病理特征相似的动物模型研究其发病机制及寻求有效治疗方法 Research Progress of Animal Model of Intrauterine Growth Retardation JIN Huihui, ZHAO Yongju (Chongqing Key Laboratory of Forage Herbivore, Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, College of Animal Science and Technology, Southwest University, Chongqing 400716,Chaina) Abstract:Intrauterine growth restriction(IUGR) is the one important complications in the perinatal period, and associated with poor perinatal health outcomes. In animal fetuses, IUGR can be caused by factors that are of maternal, placental or fetal origin.The most common cause of IUGR is placental insufficiency. However, there is a range of issues that require further investigation or investigation in more than one models. The information collected different animal models of IUGR may contribute to investigating its pathogenesis and seeking effective ways. In this article, the authors review the experimental animal models of IUGR, including natural selection, the surgical ablation of the majority of endometrial caruncles, passive smoking, matemal undernutrition, ligation of an umbilical artery. Key words: Intrauterine growth restriction; animal model; ligation of an umbilical artery引言 胎儿宫内发育迟缓(Intrauterine growth restriction，IUGR)出生体重低于同龄体重的第百分位胎儿在子宫内的生长发育受到阻碍而引起的胎儿出生体重下降的现象，是多胎妊娠的常见并发征。IUGR发生率为2.75~15.53%，围产儿死亡率较正常高4~6倍生长发育胎儿在子宫内器官生长发育不对称、缺氧、酸血症、宫内死亡，代谢紊乱、脑室出血等症状，甚至成年。 IUGR是围产期主要并发症之一，病因多而复杂胎盘功能(placental insufficiency)是最易IUGR的有实验在人类和动物的妊娠后期，影响胎儿生长发育的主要因素是胎盘向胎儿营养物质和氧胎盘血流。±0.036 VS 0.148±0.019），胎盘质量明显降低（420±68g VS 542±91g）。2006年，Wu等认为IUGR不仅会降低动物出生后的生长速度和饲料利用率，而且对动物生长后期的体组成、肉品质甚至整个繁育阶段的生育力造成负面影响。IUGR引起越来越多的工作者和生产实践者的关注建立与人类临床病理特征相似的动物模型以研究其发病机制及寻求有效的治疗方法显得尤为重要腹脐静脉穿刺羊膜腔穿刺多普勒血流测定超声生物计量学检测。多数研究以胎儿体重作为惟一预测IUGR的标准但动态监测胎儿生长情况对预后的判断却更具有价值。 羊水量是评估胎儿宫内安全性的一项重要指标羊水量