PI3K信号通路对哺乳动物HPG轴的调控作用-中国细胞生物学学报.PDF

网络出版时间：2013-06-27 10:51 网络出版地址：/kcms/detail/31.2035.Q1051.001.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(7) http ://www.cj DOI: 10.11844/cj cb.2013.07.0034 PI3K信号通路对哺乳动物HPG轴的调控作用 王 凡 肖开转 林超奇 王正朝* (福建师范大学生命科学学院, 福建省发育与神经生物学重点实验室, 福州 350007) 摘要 随着对PI3K信号通路研究的不断深入, 近年来该通路在哺乳动物中的研究(特别是 PI3K信号通路对哺乳动物生殖轴(HPG轴) 即下丘脑–垂体–性腺轴的调控上)也取得了突破性的进 展。目前, 该信号通路对哺乳动物HPG轴的调控作用的研究已成为该研究领域的焦点, 该文论述了 PI3K信号通路中的几名成员对哺乳动物HPG轴的影响, 如上游调控因子、雌激素及其受体等与下 游靶蛋白、mTOR, 从而有助于进一步解析哺乳动物卵巢功能的分子调控机制, 并为其临床应用提 供重要的参考资料。 关键词 PI3K; HPG轴; mTOR Regulatory Effects of PI3K Signaling on HPG Axis in Mammalians Wang Fan, Xiao Kaizhuan, Lin Chaoqi, Wang Zhengchao* (Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China) Abstract With the deepening study of the phosphoinositide-3 kinase (PI3K) signaling pathway, there has been breakthrough progress in the mammalian during recent years, especially in the regulation of PI3K signaling on mammalian hypothalamic-pituitary-gonadal (HPG) axis, which has become focus in the present research areas. The present article discussed the effects of several members of PI3K signaling on mammalian HPG axis, which included the upstream regulatory factors: estradiol and ER etc. and the downstream target protein: mTOR, which would help further resolve the molecular mechanism of the mammalian ovary function and provide some important reference for clinical applications. Key words phosphoinositide-