广州中医药大学-酮洛芬控释微丸片的制备和体外释放度考察.pdf

酮洛芬微丸缓释片的制备及体外释放度考察 关世侠，袁中文，周郁斌，李海刚，胡波，叶小玲，杨艳 （广州中医药大学,广东 广州 510006） ® [摘要] 目的：制备一种酮洛芬缓释片剂。方法：采用挤出—滚圆法制备酮洛芬微丸，用Eudragit RS ® 30D和Eudragit RL 30D包衣。再将包衣微丸与酮洛芬原药压片，最终制成酮洛芬缓释片。结果：体外释 放度实验显示，制备的酮洛芬缓释片在 2 h内能释药30%，剩余70%药物在随后的10 h内缓慢释放。结 论：用本方法制备酮洛芬缓释片，工艺简便，易于操作。 [关键词] 酮洛芬；挤出—滚圆法；丙烯酸树脂；微丸压片；体外释放度 [中图分类号] R943 [文献标识码] A [文章编号]1001-5213（2011） Preparation and invitroRelease ofKetoprofen Sustained-release PelletTablets Preparation and invitroRelease ofKetoprofen Sustained-release PelletTablets PPrreeppaarraattiioonnaanndd iinnvviittrrooRReelleeaasseeooffKKeettoopprrooffeennSSuussttaaiinneedd--rreelleeaasseePPeelllleettTTaabblleettss GUAN Shi-xia, YUAN Zhong-wen，ZHOU Yu-bin, LI Hai-gang，HU bo，YE Xiao-ling， YANGYan (Guang zhou Universityof Chinese Medicine, GuangdongGuangzhou 510006，China ) Abstract Objective Methods Abstract Objective Methods AAbbssttrraacctt:OObbjjeeccttiivvee prepare Ketoprofen Sustained-release tablets.MMeetthhooddss Extrusion-spheronization technique ® ® was introduced to prepare Ketoprofen pellets and Eudragit RS 30D and Eudragit RL 30D were used as coating Results Results materials. Even mix the coated pellets with Ketoprofen to prepare Ketoprofen Sustained-release tablets. RReessuullttss The data abtained proved that the formulation is useful for a Sustained-release of Ketoprofen, due to the Conclusion Conclusion persentage released in two hours is