手术治疗非连续性脊柱结核的临床疗效：一项23例患者的回顾性研究.pptVIP

The Clinical Outcomes of Surgical Treatment of Noncontiguous Spinal Tuberculosis: A Retrospective Study in 23 Cases PLOS ONE IF 3.234 (2014) Volume 9 , Issue 4 ,April 2014 The Clinical Outcomes of Surgical Treatment of Noncontiguous Spinal Tuberculosis: A Retrospective Study in 23 Cases 手术治疗非连续性脊柱结核的临床疗效：一项23例患者的回顾性研究 Jia Huang Hongqi Zhang* Kefeng Zeng Changsha, China，Xiangya Hospital of Central South University Abstract Study design:A retrospective clinical study. Objective:To evaluate the clinical efficacy of the surgical treatment of noncontiguous spinal tuberculosis (NSTB), and to discuss its therapeutic strategies. 摘要 研究设计：一项回顾性临床研究。 目的:探讨手术治疗非连续脊柱结核(NSTB)的临床疗效，并探讨其治疗策略。 Methods: We performed a retrospective review of clinical and radiographic data that were prospectively collected on 550 consecutive spinal tubercular patients including 27 patients who were diagnosed and treated as NSTB in our institution from June 2005 to June 2011. Apart from 4 patients being treated conservatively, the remainder received surgery by posterior transforaminal debridement, interbody fusion with instrumentation, posterior instrumentation and anterior debridement with fusion in a single or two-stage operation. The clinical outcomes were evaluated before and after treatment in terms of hematologic and radiographic examinations, bone fusion and neurologic status. The Oswestry Disability Index score was determined before treatment and at the last follow-up visit. 方法：我们进行了临床和影像学资料的回顾性研究，这些资料是在我们单位从2005年6月至2011年6月之间前瞻性收集的550例脊柱结核患者，其中27例患者诊断为非连续性脊柱结核并行相应治疗。除4例患者行保守治疗外，其余均接受后路经椎间孔病灶清除椎间融合内固定术，一期或二期行后路内固定联合前路病灶清除融合术。治疗前后通过血液学及影像学检查、植骨融合及神经功能状态等进行临床疗效的评价。ODI指数评分在治疗前和最后一次随访时确定。 Results: 23 patients (15 M/8F), averaged 44.6±14.2 years old (range, 19 to 70 yd), who received surgical treatment, were followed up after surgery for a mean of 52.5±19.5 months (range, 24 to 72 months). The kyphotic angle was changed significantly between pre- and postoperation (P＜0.05). The mean am