健胃愈疡颗粒治疗胃溃疡的临床观察.PDFVIP

# 606 # 2007 7 27 7 CJITW M, July 2007, Vol. 27, No. 7 林 源 廖书胜 周勇杰 李家邦 观察健胃愈疡颗粒对胃溃疡患者临床疗效及胃黏膜白 胞介素- 1B( IL- 1B) 成纤维 胞 生长因子( bFGF ) mRNA 表达的影响, 探讨其对胃溃疡的疗效机制 将56 例胃镜下确诊的胃溃疡 ( 中医辨证为肝郁脾虚证) 患者随机分为两组, 两组HP 阳性者均服用阿莫西林与甲硝唑, 治疗组( 26 例) 服 用健胃愈疡颗粒, 对照组( 30 例) 服用法莫替 丁片和硫糖铝片, 疗程均为4 周; 治疗前后观察患者的药物依从 性症状积分胃镜疗效及HP 清除率; 取胃黏膜活检, 并检测IL- 1BbFGF mRNA 表达水平 ( 1) 治 疗组药物依从率( 10010 % ) 明显优于对照组( 8617 % , P 0101) ; ( 2) 治疗后治疗组症状积分优于对照组( P 0101) ; ( 3) 两组患者胃镜下溃疡治愈率临床有效率HP 清除率比较差异无显著性; ( 4) RT-PCR 显示: 治疗后两组IL- 1B mRNA 表达明显降低, bFGF mRNA 表达增加, 与治疗前比较差异均有显著性( P 0101) , 但两组间比较差异无显著性; ( 5) 治疗后胃黏膜形态学显示两组炎症 胞浸润明显减少, 黏膜上皮 胞再生, 部分腺体重建, 呈囊状扩张 健胃愈疡颗粒有较好的药物依从性, 能明显改善患者临床症状, 降低胃黏膜IL- 1B mRNA 水平, 促进bFGF mRNA 的表达, 有促进溃疡修复作用 健胃愈疡颗粒; 胃溃疡; 白 胞介素- 1B; 成纤维 胞生长因子 Clinical StudyonEffect of Jianwei YuyangGranulein TreatingPatientswith GastricUlcer LIN Yuan, LIAO Shu-sheng, ZHOU Yong-jie, et al I nstitute of I ntegrative Traditional Chinese and Western Medicine, X iangya H osp ital of Central South University, Changsha ( 4 0008) Abstract Objective To observe the lini al effe ts of Jianw ei Yuyang Granule ( JYG) in treating patients w ith gastri ul er and its influen e on interleukin- 1B ( IL- 1B) and basi fibroblast grow th fa tor ( bFGF) mRNA expression in gastri mu osa for exploring the therapeuti me hanism. ethods Fifty-six patients with on- firmed gastri ul er unader gastros ope and differentiated as Gan-stagnant P-i defi ient syndrome w ere randomly assigned to tw o groups, the treated group ( 26 ases) treated w ith JYG and the ontrol group ( 30 ases) treated w ith famotidine and su ralfate, 4 w eeks as one therapeuti ourse. The hanges before and after treatment in lini al omplian e, symptom integral, ul er-healing rate, lini al effe tive rate, and HP- learan e rate w ere ob- served. And the gastri mu osa biopsy was fet hed for morpholo