吉兰巴雷综合征患急性期病情严重程度相关因素分析.pdf

中国医药导报 2015年4月第 12卷第 11期 窑临床医学-神经系统疾病 窑 吉兰巴雷综合征患者急性期病情严重程度 相关因素分析 高 睿 韩 露 管阳太银 第二军医大学附属长海医院神经内科袁上海 200433 [摘要] 目的分析吉兰巴雷综合征渊GBS冤急性期临床尧电生理及脑脊液特点袁并探讨其病情进展严重程度的相关 因素遥 方法 回顾性分析2000年 10月耀2014年 10月于长海医院就诊的GBS患者 113例袁 根据患者高峰期 Hughes评分划分病情等级袁用Logistic 回归模型分析病情严重程度与临床尧电生理及脑脊液指标的相关性遥 结 果急性期GBS患者年龄逸50岁渊P=0.034袁OR = 14.702袁95%CI院1.228耀175.982冤尧脑脊液IgG增高渊P=0.028袁OR = 26.652袁95%CI院1.438耀493.791冤尧周围神经轴索损害为主者渊P = 0.037袁OR = 48.529袁95%CI院1.273耀1850.656冤更易 发展为重型GBS遥 结论存在年龄逸50岁尧脑脊液IgG增高尧周围神经轴索损害的GBS患者病情相对较重袁临床 医生应针对此类患者提前实现个体化治疗遥 [关键词] 吉兰巴雷综合征曰病情严重程度曰相关因素 [中图分类号] R744.5 [文献标识码]A [文章编号] 1673-7210渊2015冤04渊b冤-0093-05 Analysis on relevant factors of severity of Guillain-Barre syndrome dur鄄 ing acutephase GAORui HAN Lu GUAN Yangtai银 Departmentof Neurology, ChanghaiHospital,the Second MilitaryMedical University,Shanghai 200433, China [Abstract] Objective To analyze the clinical, electrophysiological and cerebrospinal characteristics of Guillain-Barre syndrome (GBS)during acutephase, and to explorethe relevant factors of severity of progressive disease.Methods 113 patients with GBS admitted to Changhai Hospital from October 2000 to October 2014 were analyzed retrospectively. Hughes scale of fastigium was used to divide the illness level. Logistic regression modelwas used to analyze the corre鄄 lation of severty of illness with clinical, electrophysiological and cerebrospinal indexes. Results Among the patients with GBS during acute phase, those whose age逸50 years old (P = 0.034, OR = 14.702,95%CI: 1.228-175.982),in鄄 crease of immunoglobulin G in cerebrospinalfluid (P =0.028, OR = 26.652, 95%CI: 1.438-493.791),peripheral nerve neuraxon impairment (P =0.037, OR = 48.529, 95%CI: 1.273-1850.656)were more likely to deve