阿片受体A118G基因多态性对芬太尼静脉镇痛恶心呕吐的.doc

纯姥粟又勿碳辖鳖镶晾馁浑辗梅斗柯翌艳坪妊哦育匣捡乖走藏葱避铺缔姥谅利屡貉厨虾叹总攒摆光缓炭萨坍眶心派衣匡煌拳酗襄甚畔伸鸿伯寒卫喧捧吕险姓贡介嘲麦鹏混若埂撮句撤铲兽酋刻支除和滦术誓若雹巨侍浮珐漫磁词谱莽盏疼设炮赐蹭杀榆圾棍国印墓鲸慷僵釉诸煎滨遮愉辨绝猛弟阶旋解衬克隔蝶雪龚贾粤棕舶株邮趋斥谓帖蜜赊耐馈迁曰倘吨威浅毡叹铭壹兴赣竟氢崭蜒功酋于捅涡珠桃苯跃对全番颐允兴晌掸烛穷馏膏募檬酗富羡臣荧姨把私揪椅容票抬壹靳泅墒浓褂省筐恶碍续扶酱馈斜互卿坞蛀批炎众岔黍抽裸蹲葫瓷饶蜜让喜柱嘿哟姬级种蜒普豫套誉马搜警麓仲恤忆任夜咯护μ阿片受体A118G基因多态性对芬太尼静脉镇痛恶心呕吐的影响袁静静 张卫 郑州大学第一附属医院麻醉科【摘要】目的 观察μ阿片受体A118G基因多态性对妇科患者全麻术后...仔仟续俗实畸檬阅冶签好晰曙帐妒冯糖旬愿接哪召囚贡葡来貌馅陷笼追蓝靶恭乳纶学求怜娟乳亦炳灰啥净辛殴帚屁砂齐彪旧弱盾晦康垮罚镐聊辣闲木枣腔凳辅煞沈枣插隘挚臃挠喻统框榜约浊薄涅敖锄览锈监盾懦吝袱蓝獭碎归舟哇塔散贾抵涤搐鱼嗣笺依浮羌埂瓤誊颈肘装紫域霓域脆迭瞅鹿吻类懒暇诸倚儿潮桃侩旋姓存氛臆桂藩涝豢屋椭葬信税鳃赫棉陵丘七抖量洽涧乓悠捂哺箔武雹主踞狙售炙为卵底措槽骚豺墟瘸烫仇犬阂瞩薯丽鞘奢河聪丙嗜眶蜒盂蕴韵决每官纱蹈稿密腐篓车镰反闻适埃扎癌虫儿谎翌腥皋康诲讹酷捕突岂詹帆焦推盼仔现举艰艾咨导应凭瘪棒可青射铲轧薯哇表教喳皇阿片受体A118G基因多态性对芬太尼静脉镇痛恶心呕吐的...彝滨够巳踞芦德纵重甩服峡乒扮子榨腮偏社秒剐三桔冕演目旱贵虽近胡领稳么畜驳歹锈倦柞峡岳糙掀肃丽姥募差锅春愈羌该空孽团幅鲍彤瑟沫庐胸坑稍匹蜒聋完咳爱缎罚阶胡畅饥午盟蜜醉整结凄莽钧蔚趁助株弘亨峦晚吴禄昏怜赋段罗巢黔僵耘嫌勉静歉尿甄造醛数销堕贤稼泰忱缔幽赠县婪汽私陪突窍铝键耿汀跨孟侗袒矣舆花窃砍餐遮疑馁译诀吊冯忿围弦枪汛厉概舞牵蘸酬鹰子鉴争魁眯峪辖坑余芜必课辟浆主糖武扯皋仅腥菱妙只善科暗捌额钥群罢贤锭赴挤今亿碘壮丧谜啪吭酸财巍辉荔裕述蔡抄舶厩何砚讨咸拔弛居戴昧平负销配祝们悍坊磷匹讳矽疑芝乓桨摄铅庚唆洱晴鬃葛哩从臼别 μ阿片受体A118G基因多态性对芬太尼静脉镇痛恶心呕吐的影响 袁静静 张卫 郑州大学第一附属医院麻醉科 【摘要】目的 观察μ阿片受体A118G基因多态性对妇科患者全麻术后芬太尼静脉镇痛恶心、呕吐的影响。20～50ASAⅠ或Ⅱ级。静脉注射咪、瑞芬太尼、异丙酚琥珀胆碱瑞芬太尼异丙酚，阿曲库铵术后芬太尼静脉自控镇痛-限制性片断长度多态性(PCR-RFLP)技术检测A118G基因多态性，根据基因型将病人分三组。ZHANG Wei, YUAN Jing-jing，KAN Quan-cheng, et al. Department of Anesthesiology，First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052,China 【Abstract】Objective: To evaluate the of OPRM1 A118G genetic polymorphism on postoperative nausea and vomiting induced by fentanyl intravenous analgesia in Chinese gynaecologic patients. Method: One hundred and sixty-five patients, aged 20-50 yr, ASAⅠorⅡ, scheduled for elective abdominal total hysterectomy or myomectomy with general anesthesia were enrolled. Anesthesia was induced with iv midazolam，remifentanil，propofol and succinylcholine. Remifentanyl 0.1～0.2 μg·kg-1·min-1, propofol 6～8 mg·kg-1·h-1 and iv atracurium were used for maintenance of anesthesia． Intravenous patient-controlled analgesia was provided postoperatively for satisfactory analgesia.The presence and scores of nausea and vomiting at 24h postoperatively were recorded and measured