Nucleotides and Nucleic acids-I-第六讲.pdf

NucleotidesandNucleotidesandNucleotidesNucleotides  andand   Nucleic AcidsNucleic AcidsII Xianming DENG Xianming DENG SchoolofLifeSciences,XiamenUniversity 1010-1414 Agenda: An OverviewAgenda: An Overview  Some Basics  Nucleic Acid Structure   Nucleic Acid Chemistry  Other Functions of Nucleotides  SomeBasicsSome Basics  1. Some Basics  1.1 Nucleic acid（核酸）  Thetransferofgeneticinformationtonewcellsisaccomplished Thetransferofgeneticinformationtonewcellsisaccomplished throughtheuseofbiomoleculescallednucleicacids: –ribonucleicacid(RNA)—foundmainlyinthecytoplasmofliving cells –deoxyribonucleicacid(DNA)—foundmainlyinthenucleusof livingcells  DNAandRNAarepolymersconsistingofrepeatingsubunits callednucleotides. Chemical structure  1. Some Basics  aspects Nuceloside（核苷核苷）, Nucleotide（核苷酸核苷酸） and Nucleic acid（核酸） AAnucleonucleossideideconsistsofanitrogenousbase(consistsofanitrogenousbase(purinepurineororpyrimidinepyrimidine)and)and pentosesugar. AAnuclleotidideconsiistsoffaniitrogenousbbase((puriineorpyriimidiidine)),a pentosesugar,andoneormorephosphategroups. Nucleic acidsarepolymersofnucleotides,joinedtogetherby phosphodiesterlinkagesbetweenthe5-hydroxylgroupofone pentoseandthe3pentoseandthe3-hydroxylgroupofthenexthydroxylgroupofthenext. Schematic view phosphate