抗病毒药-龙亚秋.pdf

Medicinal Chemistry Lectures Antiviral Agents Dr. Ya-Qiu LONG Shanghai Institute of Materia Medica April 2, 2004 -Transmitted through the respiratory, gastrointestinal and genital tracts, and the skin, urine, blood, and placenta. Viruses Size: 0.02 ~ 0.4 µm Consist of a nucleic acid core DNA RNA Capsid （病毒壳体）+ Protein Coat Nucleocapsid Envelope composed of glycoproteins that are viral antigens Complete package is known as VIRION Viruses Infecting Animals and Humans Virus Group Species Diseases DNA-Containing Viruses Adenovirus Respiratory tract and eye infections Many types （腺病毒） (keratitis角膜炎) Herpes simplex virus types Encephalitis （脑炎）, eye infections, 1 2 skin diseases, genital infections Varicella-zoster （ 水痘） Chickenpox (children) Herpesvirus Herpes zoster （带状疱疹） Shingles (adults) （疱疹病毒） Cytomegalovirus Cytomegalovirus diseases Epstein-Barr virus (Mononucleosis), hepatitis (animal (非洲淋巴细胞瘤病毒) and human), Marek’s virus disease, Epstein-Barr virus disease Human wart virus （疣） Animal and human warts Rapovavirus Polyoma virus Salivary gland infectionProgressive multifocal leukoencephalopathy SV 40 （脑白质病） Poxvirus Variola Smallpox （天花）, cowpox, （痘病毒） Vaccinia