抑郁性失眠的药物治疗进展（Progress in the treatment of depressive insomnia）.doc

抑郁性失眠的药物治疗进展（Progress in the treatment of depressive insomnia） Depressive insomnia was associated with depression in somatic symptoms, the main features of REM sleep latency, wake up early, deep sleep, and REM sleep, wake up less difficult to fall asleep again, every night sleep time was significantly reduced the severity of insomnia usually have a direct relationship with the severity of depression, so the treatment of insomnia can not simply use sleeping pills or behavioral therapy, more important is the treatment of depression. Through comparing several antidepressants, this article discusses the drug treatment of depressive insomnia. 1 drug therapy Monoamine oxidase inhibitors (MAOI), is a drug with selective inhibition of monoamine oxidase activity in vivo, its mechanism is through inhibition of monoamine oxidase activity, reduce the degradation of monoamine neurotransmitters in central nervous system, relative increase of monoamine neurotransmitter levels, resulting in antidepressant effect. This drug is applied to a class of earlier clinical antidepressants are iproniazid, phenelzine and other drugs, but because of more adverse reactions, and the effect is not as good as later tricyclic antidepressants, the clinical use of less than. In recent years, developed a new type of selective monoamine oxidase A inhibitor, on behalf of the drug for moclobemide, its pharmacological effects of selective inhibition of MAOA, and the inhibition is reversible, no cholinergic receptor blockade, retained the antidepressant effect, adverse reaction and abandon the traditional TCA MAOI anticholinergic adverse reaction, its anti depression effect of rapid onset, low adverse reactions, is a safe and effective antidepressant. Tricyclic antidepressants (TCA), which belongs to the first generation of monoamine reuptake inhibitors, 5-HT and NE can not only inhibit the presynaptic reuptake, and with anticholinergic effects, applicable to all types of depression, and the curative effec