抗核抗体（Antinuclear antibody）.doc

抗核抗体（Antinuclear antibody） Anti nuclear antibody Encyclopedia Antinuclear antibodies (antinuclear, antibody, ANA) also known as anti DNA antigen antibody, is a set of various components of deoxyribonucleoprotein its eukaryotic cell nuclear antigen (DNP), DNA, extraction (ENA) and RNA as general target antigen antibody, can react with all the animals the nucleus, mainly exists in the serum, can also be found in pleural effusion, synovial fluid and urine. Catalog [hidden] Brief introduction of principle Detailed content Anti nuclear antibodies classified against DNA antibodies Extractable nuclear antigen Anti histone antibody Anti centromere antibody Anti nucleolar antibody Brief introduction of principle Detailed content Anti nuclear antibodies classified against DNA antibodies Extractable nuclear antigen Anti histone antibody Anti centromere antibody Anti nucleolar antibody [edit this paragraph] principle brief introduction In a variety of autoimmune diseases were positive rate of different levels of anti nuclear antibodies, such as systemic lupus erythematosus (SLE, 95%~100%), rheumatoid arthritis (RA, 10%~20%), mixed connective tissue disease (MCTD, 80%~100%), Sjogren syndrome (SjS, 10%~40%) and systemic sclerosis (85%~90%). Lupus hepatitis (95%~100%), primary biliary cirrhosis (95%~100%), but after treatment with cortical hormone, can reduce the rate of positive. Antinuclear antibodies in patients with rheumatoid arthritis in about 20% ~ 50%IgG ANA positive, the positive rate of children with rheumatoid ANA about 19% ~ 35%, the positive rate associated with iridocyclitis were higher (505~90%), the positive expression of ANA indicates a chronic rheumatoid cyclitis may. It has been found that 75% of rheumatoid patients have polymorphonuclear leukocyte specific ANA or antineutrophil cytoplasmic antibodies (ANCA) which can damage the white nucleus. [edit this paragraph] details Antinuclear antibodies are autoantibodies against a molecular complex of DNA, RNA, protein