抗生素相关性腹泻的诊断与治疗进展（Advances in the diagnosis and treatment of antibiotic associated diarrhea）.doc

抗生素相关性腹泻的诊断与治疗进展（Advances in the diagnosis and treatment of antibiotic associated diarrhea） Advances in the diagnosis and treatment of antibiotic associated diarrhea Update Date: 06-10 [Abstract] details of the etiology, diagnosis and treatment of antibiotic associated diarrhea latest progress, in this era of universal use of antibiotics, this paper can be referred to clinicians. Antibiotic associated diarrhea (antibiotic associated diarrhea, referred to as AAD) refers to the use of antibiotics after secondary diarrhea, adverse drug reactions are more common, the incidence varies according to different antibiotics, about 5% ~ 39%, 1, 2. According to the severity of AAD, including diarrhea, colitis or pseudo membranous colitis. Pseudomembranous colitis (pseudomembranous colitis, referred to as PMC) refers to a serious condition, a special type of pseudo membrane formation in the colonic mucosa, if not timely, given a reasonable treatment, can lead to complications, the mortality rate as high as 15% to 24%. The occurrence of this disease, a more consistent view is that antibiotic bacteria destroyed the natural ecological balance of the intestines, namely physiological bacteria decreased, while the number of aerobic bacteria and facultative anaerobic bacteria increased, which is related to the pathogenesis of PMC is mainly Clostridium perfringens bacillus (Clostridium difficile, referred to as CD) 2, it produces a toxin, toxin A enterotoxin, toxin B cell toxin, 2 toxins can cause intestinal mucosal injury and inflammation. Other bacteria are Bacillus perfringens, Staphylococcus aureus, Klebsiella, and Salmonella (3). All drugs that can fight bacteria can almost cause AAD, and can be found in Lincomycin (lincomycin), azithromycin (azithromycin) and ampicillin (ampicallin) [4]. In addition, cephalosporins, penicillins and so on are common, and aminoglycoside antibiotics are less common. But the anti tuberculosis bacteria, fungi and antibacterial agents against parasites