抗真菌药（Antifungal agents）.doc

抗真菌药（Antifungal agents） Antifungal agents are classified into antifungal agents, antifungal agents and broad-spectrum antifungal agents. I. antibiotics Amphotericin B (amphotericin, B) Broad-spectrum antifungal agent [pharmacological effects] polyene, deep fungi have a strong inhibitory effect First treatment for deep fungal infection [Mechanism] selective and fungal cell membrane ergosterol binding, increase the permeability of death. High concentration sterilization. Ineffective for bacteria and toxic to mammals. [clinical application] oral for intestinal fungal infection Intravenous administration is used for systemic fungal infections Intrathecal injection for fungal meningitis [adverse reactions] toxicity is greater Acute toxic reaction Renal damage Hematological toxicity Toxicity of cardiovascular system Prevention measures: First, give antipyretic analgesics and antihistamines, and give corticosteroids at the same time Potassium supplementation Regular monitoring of hematuria routine, liver and kidney function, blood potassium, ECG Those who have poor liver and kidney function are cautious Griseofulvin (griseofulvin) For the narrow shallow antifungal drug system [Mechanism] penetrate into the stratum corneum of the skin, prevent tubulin polymerization, inhibit the mitosis of fungi, interfere with the synthesis of fungal nucleic acid, prevent the continued invasion of ringworm, and inhibit all kinds of ringworm bacteria. [adverse reactions] more or less heavy. The gastrointestinal tract and the blood system are the inducers of liver drug enzymes, which reduce coumarin action. [] the clinical application of oral treatment of tinea capitis, tinea corporis, tinea cruris, tinea pedis and onychomycosis superficial fungal disease treatment. Route of administration: oral administration is effective, fat food and ultra fine particle preparation increase absorption, and external use is invalid. Nystatin (nystatin) [action mechanism] polyene, the action and mechanism of