抗着丝点抗体71例临床分析（Clinical analysis of 71 cases of anti centromere antibody）.doc

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抗着丝点抗体71例临床分析（Clinical analysis of 71 cases of anti centromere antibody）.doc

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抗着丝点抗体71例临床分析（Clinical analysis of 71 cases of anti centromere antibody）

抗着丝点抗体71例临床分析（Clinical analysis of 71 cases of anti centromere antibody） Clinical analysis of 71 cases of anti centromere antibody 2009-10-17 Tang Fulin Li Mingjia Wang Guosheng for the sea Abstract Objective: To investigate the relationship between anti centromere antibody (ACA) and clinical diseases. Methods: the clinical data of 71 patients with ACA positive were retrospectively reviewed. Results: ACA can appear in a variety of diseases, including 30 cases of systemic sclerosis (42.2%), 10 cases of Sjogrens syndrome (14.1%), 6 cases of systemic lupus erythematosus (8.5%), 5 cases of rheumatoid arthritis (7%), 5 patients with localized scleroderma (7%), 4 cases of Raynaud phenomenon but the diagnosis is not clear (5.6%), CREST syndrome and overlap syndrome, unexplained cirrhosis, thromboangiitis obliterans 2 cases (2.8%), primary biliary cirrhosis, sclerosing cholangitis, chloasma with vitiligo in 1 cases (1.4%). Conclusion: ACA related clinical symptoms were Raynauds phenomenon (57.7%) and skin sclerosis (53.5%). ACA is not a specific antibody to CREST syndrome. Keywords anti centromere antibody; systemic sclerosis; CREST syndrome; THE CLINICAL ANALYSIS WITH WITH ANTICENTROMERE ANTIBODIES Tang 71 CASES Fulin, Zhan Xiaohai, Li Mingjia, Wang Guosheng Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing, 100730. Abstract Objective:To study the association of anticentromere antibodies (ACA) with various diseases.Methods:A total of patients with positive ACA were 71 retrospected.Results:There were 30 patients with systemic sclerosis (42.2%), 10 with s syndrome Sjogren (14.1%), 6 with systemic lupus erythematosus (8.5%), 5 with rheumatoid arthritis and localized sclerosis (respectively, 7%) 4 with only Raynaud s phenomenon without any definite diagnosis (5.6%), 2 with CREST syndrome, overlap syndrome, cirrhosis of unknown causes and Buerger s disease (2.8%) respectively, and 1 with primary billiary cirrhosis, sclerous cholangitis, and chloa