疏水纤维素及其自组装纳米球的合成与表征.pdf

Polym. Bull. (2012) 69:389–403 DOI 10.1007/s00289-012-0729-7 ORI GIN AL PA PER Synthesis and characterization of hydrophobic long-chain fatty acylated cellulose and its self-assembled nanoparticles Yanzhu Guo • Xiaohui Wang • Dong Li • Hong Du • Xiaoying Wang • Runcang Sun Received: 3 October 2011 / Revised: 4 January 2012 / Accepted: 29 February 2012 / Published online: 9 March 2012 Springer-Verlag 2012 Abstract In this paper, a series of cellulose-based hydrophobic associating polymers were prepared by homogeneous acylation of microcrystalline cellulose with long-chain acyl chlorides including octanoyl, lauroyl, and palmitoly chlorides in the solvent of N,N-dimethylacetamide/lithium chloride (DMAc/LiCl) using pyridine as acid scavenger. Through controlling the chain length of fatty acyl chlorides and the molar ratio of acyl chlorides vs anhydroglucose unit, the hydro- phobic cellulose derivatives with degrees of substitution in the range of 0.02–1.75 were successfully obtained. The chemical structures and properties of these hydrophobic derivatives were characterized by elemental analysis, FT-IR, CP/MAS 13C NMR, X-ray diffraction, and the thermogravimetry analysis. It was also found that, the cellulose-based polymers achieved an excellent solubility in organic sol- vents, such as benzene, methylbenzene, and pyridine, with the introduction of hydrophobic side chain into the cellulose backbone. Furthermore, it was found that these hydrophobic cellulose derivatives could self-assemble into spherical nano- particles in aqueous solution, which indicates a tremendous potential of applications in pharmaceutical and medical fields. Keywords Cellulose-based polymers Acylation Self-assembly Y. Guo X. Wang () D. Li H. Du X. Wang R. Sun () State Key Laboratory of Pulp and Paper Engineerin