TP方案与PF方案化疗治疗晚期食管癌的近期疗效对比分析.pdfVIP

2017 NO.7 China Foreign Medical Treatment 中外医疗 药 物 与 临 床 DOI :10.16662/j .cnki .l 674-0742.2017.07.099 T P 方案与P F 方案化疗治疗晚期食管癌的近期 疗效对比分析 陈青，马德 江苏省靖江市人民医院肿瘤科，江 苏 靖 江 214500 [摘要]目的探讨T P 方案化疗与P F 方案治疗晚期食管癌的近期疗效。方法回顾性分析2013年 4 月一2016年 3 月 该院收治的晚期食管癌患者60例，分为T P 组(n=36;紫杉醇135 mg/m2 d 1;顺钼20 mg/m2 d 1-3)与 P F 方案组(n=24; 5-氟尿嘧啶500 mg/m2泵持续推注d 1-5;顺钼25 mg/m2 d 1-3);观察两组患者的近期疗效及毒性反应。结果T P 组近 期有效率为69.44%，明显比P F 组髙(41.67%)(P0.05);T P 组不良反应发生率为80.56%，P F 组为83.33%，两组患者间 不良反应发生率组间差异无统计学意义(P0.05)。 结论 TP (紫杉醇联合顺钼)方案化疗能提髙晚期食管癌患者的近 期疗效，同时其毒副反应发生率并未增髙，可认为安全有效。 [关键词]T P 方案;P F 方案；晚期食管癌 [中图分类号]R4 [文献标识码] A [文章编号]1674-0742(2017)03(a )-0099-03 Comparative Analysis of Long-term Curative Effect of TP Plan and PF Plan Chemotherapy in Treatment of Esophageal Cancer C H E N Qing, MA De Department of Oncology , Jingjiang People, s Hospital , Jingjiang , Jiangsu Province , 214500 China [Abstract] Objective To observe and analyze the long-term curative effect of TP plan and PF plan chemotherapy in treat ­ ment of esophageal cancer . Methods 60 cases of patients with esophageal cancer admitted and treated in our hospital from April 2013 to March 2016 were retrospectively analyzed , and divided into the TP group and PF group , the TP group (n= 36) adopted the taxinol of 135 mg/m2 d 1 and cis-platinum complexes of 20 mg/m2 d 1-3, the PF group (n=24) adopted the 5- fluorouracil of 500 mg/m2 and cis-platinum complexes of 25 mg/m2 d 1-3, and the long-term curative effect and toxic reac ­ tion of the two groups were observed . Results The lo