microCT在血管成像方面的应用.pdf

micro-CT在血管成像方面的应用 主要内容  micro-CT 发展  micro-CT应用领域  血管成像( 文献1)  血管DCE 成像( 文献2) micro-CT 发展 micro-CT 、显微CT 、微型CT 、微CT 、微焦点CT  Microscopic computed tomography (micro-CT) was first developed in the early 1980s.  Fan beam or Cone beam  the development of a cone-beam reconstruction algorithm by Feldkamp et al. (FDK) in the later 1980s greatly facilitated bench- top micro-CT. Source Object Detector 扇形束 锥束 Plate micro-CT发展  国外的GE(美国) 、SkyScan(比利时) 、Comet(德国) 、 Scanco(瑞士) 、BIR(美国) 、Toshiba( 日本) 、 PerkinElmer 等知名公司推出了自己的Micro-CT产品  国内中科凯盛  国内清华、北航、中科院高能所、先研院、自动化所、 天津大学、中国工程物理研究院应用电子学研究所、西 电、四医大、信息工程大学、东南大学等 micro-CT发展 micro-CT发展 Skyscan- 1176 VivaCT 40 ACTIS 200/225 Y.CT Precision micro-CT应用领域 肝小叶 肝(实质) 细胞 粒腺体 Small rodents are of the order of 10 cm in size, their organs are 1 cm, and their tissue basic functional units (BFU) are a nominal 100 μm in diameter. Cells are of the order of 5– 10 μm in diameter. The three levels of microscopic-CT can image the entire animal/organ, BFU, or cell as a single volume image, respectively.  Micro-CT优点：分辨率高、分辨率各向同性、机械结构简单、小型化、 扫描速度快  Most current in vivo MicroCT scanners have resolutions ranging from 100 to 30 μm  ex vivo scanners have resolutions from 30 to 1 μm “Molecular Imaging of Vessels in Mouse Models of Disease ”Eur J Radiol. 2009 May ; 70(2): 305–311. “Current Status of Developments and Application