王华东 脓毒症的病理生理学从基础到临床.pdf

脓毒症的病理生理学: 从基础到临床 王华东 （暨南大学医学院病理生理学系） 广东省自然科学基金重点项目 国家自然科学基金资助项目 一、脓毒症相关概念的新认识 • Roger Bone and colleagues (1991) :sepsis as a systemic inflammatory response syndrome (SIRS) that can occur during infection (American College of Chest Physicians/Society of Critical Care Medicine). Systemic inflammatory response syndrome (SIRS) criteria (≥2 must be present) • Body temperature38 ℃or 36 ℃; • Heart rate 90 beats per minute; • Respiratory rate 20 breaths per minute or PCO2 32 mmHg; 9 9 • White blood cell count 12 ×10 /L or 4.0 ×10 /L 2001 年底在华盛顿由危重症医学会( SCCM)、 欧洲加强治疗医学会( ESICM)、美国胸科医师协 会(ACCP )、美国胸科协会(ATS)、外科感染学会 ( SIS) 脓毒症概念定义、诊断标准进行重新规定， 同时制定了PIRO脓毒症的分阶段系统 1)一般指标;2)炎症指标;3)血流动力学指标;4) 器官功能障碍参数;5)组织灌流参数。 2005年， 确定儿童脓毒症的诊断标准 The definition of Sepsis Systemic inflammatory response syndrome caused by severe infection, leading to a hyperactive and unbalanced network of inflammatory mediators. Vascular permeability, cardiac function and metabolic balance are affected, resulting in tissue necrosis, multi-organ dysfunction and death. Pathogen-associated molecular patterns (PAMPs) and (damage) danger-associated molecular patterns (DAMPs) during sepsis. Peter A. Ward. EMBO Mol Med (2012) 4, 1234–1243 Glossary of sepsis (Peter A. Ward, 2012) • Sepsis: An illness in which the body has a systemic inflammatory response syndrome (SIRS) to bacteria, other pathogens or sterile inflammation (sepsis-like response) • Severe sepsis: Sepsis complicated by end-organ dysfunction, as signalled by altered mental status, hypotension, elevated creatinine concentration or evidence of disseminated intravascular coagulopathy. • Septic shock: Acute circulatory failure induce