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The effect of chitosan on the endothelial regeneratioin and
neointimal proliferation after balloon angioplasty of arterial
in rat
Abstract
Objective :To investigate the effect of chitosan on the endothelial
regeneratioin and neointimal proliferation after balloon angioplasty of right carotid
arterial in rat 。
Methods: Endothelial denudation of arterial in rat were performed with 2F
balloon catheter. 50 SD rats were randomly divided into the control group and the
chitosan group. Arterial were harvested on 0 day;7 days;14 days;28 days and 35 days
after the injury. The reendothelialization and the neointimal hyperplasia were
observed cross-sections stained with hematoxylin-eosin from the injured segments
processed for histological and morphological study by computer-assisted picture
analysis system.
Result: chitosan enhanced the reendothelialization of the injured arterial
determined VEGF staining. The absolute reendothelialization was observed in 14
days in chitosan group but in 28 days in the control group. Intimal hyperplasia and
lumen stenosis can be seen on the 7 days after injury. At the 28th day the intimal
thickening reached at a peak. In the chitosan group the intimal thickening reached at a
th
peak at the 14 day. There were significant difference of neointimal in the chitosan
group and the control group on the 14 th day;28 th day and 35 th day .
Conclusions: chitosan is effective on intimal hyperplasia and lumen
stenosis after arterial injury by inhibiting neointimal proliferation which is related to
the reendothelialiazation.
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