苦参碱、PD98059与U0126对肝癌MAPK、JAK-STAT信号转导通路地调控作用.pdf

英文摘要 of Theeffect on matrine，PD98059，U0126 signaling transductionof in MAPKandJAK．STAT SMMC．7721cells ABSTRACT acommon carcinoma(HCC)is objective：Hepatocelhdar tumor tractwith of and digestive poor factorscontributeto ofthis cancel-,but genetic carcinogenesis thetruemechanismremainsunknown．Newanticanceris drug filedforHCCresearchSOfartoadvanced hypercompetitive transductionhasa roleon breakthrough．Cell signaling subtle ontransduction carcinogenesis，anychanges waymay inducecelltodifferentoutcomeas and apoptosis，immortal senescence．Ras／Raf／ERKandJAK—STAT of signalingtyrosine kinase contributedtotumor influences protein pathway process HCC Inthis treatHCCcell developmentdramatically．study,we 1ineofS心C．7721 cellwithChineseherbal martrine，MEK 16 transductioninhibitorPD98059andU0 to signaling way theireffect on SOastoHCCcell study signali