Amberlite IR-120一种可重复利用的微波辅助条件下胺类化合物与甲酸N-甲酰化反应的催化剂.pdfVIP

2010 Chinese Journal of Catalysis Vol. 31 No. 5 Article ID: 0253-9837(2010)05-0518-03 DOI: 10.1016/S1872-2067(09)60064-4 Communication: 518–520 Amberlite IR-120: A Reusable Catalyst for N-Formylation of Amines with Formic Acid Using Microwaves * Madhusudana Reddy MVTHUKUR BHOJEGOWD, Aatika NIZAM, Mohamed Afzal PASHA Department of Studies in Chemistry, Central College Campus, Bangalore University, Bengaluru 560 001, India Abstract: A rapid and practical green route for the N-formylation of amines with formic acid using Amberlite IR-120 as a catalyst is de- scribed. This method provides an efficient and much improved modification over the reported methods in terms of yield, reaction time, and work-up procedure. A wide variety of substituents is tolerated, which is not the case for existing procedures. Key words: N-formylation; Amberlite IR-120; formic acid; amine; microwave CLC number: O643 Document code: A Since the first report by Fieser et al. [1] on the pounds still remains an active research area. N-formylation of amines, a number of strategies have been On the other hand, a “green” reaction should ideally be developed for their synthesis because of their importance as conducted under solvent-free conditions with minimal or no intermediates in the preparation of several fine chemicals side products and with the utmost atom economy [21]. One [1] and pharmaceutically important compounds such as way to achieve this is b