第10章+细胞凋亡.pdf

第十章 细胞凋亡 1 Outline Cell death Cell apoptosis Cytochrome c and apoptosis 2 1、Cell death Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, or may result from such factors as disease, localized injury, or the death of the organism of which the cells are part. Kinds of cell death include ： Programmed cell death (or PCD) is cell death mediated by an intracellular program • Apoptosis or Type I cell-death • Autophagy or Type II cell-death • Programmed necrosis, called necroptosis (坏 死性凋亡), has been recognized as an alternate form of programmed cell death. It is hypothesized that necroptosis can serve as a cell-death backup to apoptosis when the apoptosis signaling is blocked by endogenous or exogenous factors such as viruses or mutations. Unprogrammed cell death • Necrosis Divers