皮肤功能降低增加代谢综合征风险-生理学报.pdfVIP

生理学报Acta Physiologica Sinica , June 25, 2012, 64(3): 327–332 327 综 述 皮肤功能降低增加代谢综合征风险 1 1 1 1,2,* 刘星星 ，李达 ，李春艳 ，周士胜 1 2 116622 大连大学医学院生理学教研室；辽宁省高校生物物理学重点实验室，大连 摘 要：代谢综合征是多种心血管疾病危险因子聚集的症候群，其发病与环境因素和生活方式有密切关系。环境因素主要 是指那些增加体内异型生物质水平的因素(例如环境污染、药物、高肉类饮食和食物添加剂等) ，而生活方式主要是可以影响 机体的毒物代谢和排泄能力的因素。皮肤是人体的最大器官，在转化和排泄异型生物质及维持体内脂质稳态方面，都起着 重要的作用，但这些功能受生活方式和环境温度的影响。低环境温度和久坐生活方式引起的皮肤生物转化和排泄能力降 低，可能是代谢综合征的一个重要的危险因素。本文将简要讨论皮肤功能特点与代谢综合征发病的关系。 关键词：皮肤；代谢综合征；异型生物质；氧化应激；胰岛素抵抗 中图分类号：R363.1 ；R363.2 Decreased skin function may be a risk factor for metabolic syndrome 1 1 1 1,2,* LIU Xing-Xing , LI Da , LI Chun-Yan , ZHOU Shi-Sheng 1Department of Physiology, Medical College; 2Key Laboratories of Biophysics of Liaoning Province, Dalian University, Dalian 116622, China Abstract: The metabolic syndrome, a cluster of risk factors for cardiovascular disease, is closely related to environmental and life- style risk factors. Increasing evidence suggests that environmental risk factors may involve an increase in xenobiotic exposure, for example due to environmental toxins, medications, high meat intake, food additives and supplements; while lifestyle risk factors, such as sedentary lifestyles, may involve a decrease in the detoxification and elimination of xenobiotics. The skin, the body’s largest organ, plays a distinct role in the detoxification and elimination of xenobiotics and the body lipid homeostasis, which is affected by sedentary lifestyle and physical activity, as well as by ambient temperature. Thus, it seems that decreased skin biotransformation and excretion, for example due to low ambient temperature and sedentary lifestyle, may be an important risk factor for metabolic syndrome. This review aims to provide insight into the role of the skin in the development o